首都医科大学附属北京世纪坛医院

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晴 20℃~8℃ 风向:西南风微风级

崔磊主任医师

科室: 整形美容外科

擅长:

先后从事整形外科临床、干细胞与组织工程研究、临床应用转化等工作。

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个人简介 学术任职 主研方向 获奖情况 学术论著

[职称] 教授,博士生导师

[职务] 中心实验室主任

[学位] 医学博士

教育背景/工作经历

1986/8-1991/8: 南京铁道医学院医疗系 学士学位

1991/8-1993/8: 北京铁路总医院外科 住院医师

1993/8-1998/8: 上海第二医科大学 博士学位

1998/8-2001/5: 上海第二医科大学附属第九人民医院整形外科 主治医师

2001/5-2005/6: 上海第二医科大学附属第九人民医院整形外科 副主任医师

2003/1 -2012/12: 上海组织工程研究与开发中心 副主任

2004/1-2010/1: 组织工程国家工程研究中心 常务副主任,教授、博士生导师

2006/1-2014/12: 上海交通大学医学院附属第九人民医院整形外科 研究员

2014/12-至今: 同济大学医学院再生医学系 教授、博导

2015/5-至今: 首都医科大学附属北京世纪坛医院 中心实验室 主任,教授、博导

2017/5-至今: 首都医科大学附属北京世纪坛医院整形外科 代理主任

联系方式

联系电话:63926511

中国医促会肿瘤整形外科分会常委

中国整形美容协会抗衰老分会 常务理事、副秘书长

任中国生物医学工程学会理事

中国整形美容协会抗衰老分会常务理事

“中华医学奖”评审专家

先后从事整形外科临床、干细胞与组织工程研究、临床应用转化等工作。

承担国家/省部级科研项目:

1)北京市医管局扬帆计划临床创新项目  可注射性组织工程骨治疗股骨头坏死  2016.1-2018.12,100万元。(主持单位:首都医科大学附属北京世纪坛医院)

2)国家自然科学基金面上项目 81471798 主持  锶调控脂肪干细胞成骨-成脂分化的表观遗传机制与激素性股骨头坏死修复

2015-2019年, 72万元。(主持单位: 同济大学)

3)国家自然科学基金面上项目,81271724, 主持  人毛囊干细胞成骨转分化的分子机制研究及骨缺损修复  2013/01-2017/12,80万元,(主持单位: 上海交通大学)

3)国家“863”计划, 2009AA02Z110, 主持  应用脂肪源干细胞构建组织工程血管的关键技术研究与产品开发  2009/1-2011/12 , 176万元, 已结题,(主持单位: 上海交通大学)

4)国家自然科学基金面上项目 ,30970743,主持  成软骨横向分化真皮成纤维细胞修复犬半月板缺损及分化细胞体内转归的研究  2010/1-2012/12, 30万元,已结题,(主持单位: 上海交通大学)

5) 国家自然科学基金面上项目, 30672190 , 主持  同种异体脂肪干细胞组织工程骨修复颅骨缺损及免疫调控机制  2007/1-2009/12 29万元,已结题,主持(主持单位: 上海交通大学)

6) 国家“973”计划子项目, 2005CB522700  组织工程重要基础科学问题研究  2005.12-2010.11, 150万元,已结题,参加(主持单位: 上海交通大学)

1. 组织工程化组织构建关键技术研发与应用  国家技术发明二等奖(2008) 第2完成人

2. 干细胞构建组织工程骨的基础研究与临床应用  教育部科技进步二等奖(2008) 第1完成人

3. 基于组织工程化角膜基质构建的角膜缺损修复研究  上海医学科技奖二等奖(2006) 第1完成人

4. 组织工程皮肤的基础和应用研究  上海医学科技奖二等奖(2005) 第3完成人

5. 组织工程化肌腱的应用基础研究  上海市科技进步一等奖(2004) 第3完成人

6. 修复骨组织缺损的组织工程学基础与临床应用研究  中华医学科技奖三等奖(2003) 第2完成人

专著:

1、《皮肤美容学 》(雷万军 崔磊主编2013年 ) 中国中医药出版社

2、《黄家驷外科学》(吴孟超、吴在德主编,人民卫生出版社2008年) 撰写“组织工程学”章节

3、《组织工程学》(曹谊林主编,科学出版社2007年) 副主编

4、《组织工程理论与实践》(曹谊林主编,上??蒲Ъ际醭霭嫔?004年) 副主编

近年发表文章(仅包括第一与通讯作者):

1. Zhang K, Song L, Wang J, Yan S, Li G, Cui L#, Yin J. Strategy for constructing vascularized adipose units in poly(lglutamicacid) hydrogel porous scaffold through inducing in-situ formation of ASCs spheroids. Acta Biomater.2017;51:246-257.

2. Xue X, Liu Y, Wang Y, Meng M, Wang K, Zang X, Zhao S, Sun X, Cui L#, Pan L, Liu S.MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1, SOCS6, and PTEN. Oncotarget. 2016 ;7(51):84508-84519.(co-correspondence)

3. Yan S, Zhang X, Zhang K, Di H, Feng L, Li G, Fang J, Cui L#, Chen X, Yin J. Injectable in situ forming poly(Lglutamicacid) hydrogels for cartilage tissue engineering. J. Mater. Chem. B, 2016; 4: 947-961. (co-correspondence)

4. Zhang K, He S, Yan S, Li G, Zhang D, Cui L#, Yin J. Regeneration of hyaline-like cartilage and subchondral bone simultaneously by poly- (L-glutamic acid) based osteochondral scaffolds with induced autologous adipose derived

stem cells. J. Mater. Chem. B, 2016; 4: 2628-2645. (co-correspondence)

5. Kaisaier A, Munila M, Abudusaimi A, Cui L#. Differentiation of human adipose derived stem cells into smooth muscle cells is modulated by CaMKII. Stem Cells International. Stem Cells Int, 2016 (19):1-9. (correspondence)

6. Li C, Bi W, Gong Y, Ding X, Guo X, Sun J, Cui L#, Yu Y. Transforming growth factor-beta1 inhibits tissue engineering cartilage absorption via inducing the generation of regulatory T cells. J Tissue Eng Regen Med. 2016;10(2):E113-20.(co-correspondence)

7. Gu H, Huang Z, Yin X, Lu L, Cui L#. Role of c-Jun N-terminal kinase in the osteogenic and adipogenic differentiation of human adipose-derived mesenchymal stem cells. Exp Cell Res. 2015,339(1):112-21.(co- correspondence)

8. Jianjun Fang, Qi Yong, Kunxi Zhang,Wentao Sun, Shifeng Yan, Lei Cui# and Jingbo Yin. Novel injectable porous poly(g-benzyl-L- glutamate) microspheres for cartilage tissue engineering: preparation and evaluation. J. Mater.Chem. B, 2015, 3, 1020–1031

9. Zhang K, Yan S, Li G, Cui L#, Yin J. In-situ birth of MSCs multicellular spheroids in poly(L-glutamic acid)/chitosan scaffold for hyaline-like cartilage regeneration. Biomaterials, 2015. 71: p. 24-34.(co-correspondence)

10. Fang J, Zhang Y, Yan S, Liu Z, He S, Cui L, Yin J. Poly(L-glutamic acid)/chitosan polyelectrolyte complex porous microspheres as cell microcarriers for cartilage regeneration. Acta Biomater. 2014 Jan;10(1):276-88.(IF:5.1共同通讯作者)

11. Zhang K, Zhang Y, Yan S, Gong L, Wang J, Chen X, Cui L, Yin J. Repair of an articular cartilage defect using adipose-derived stem cells loaded on a polyelectrolyte complex scaffold based on poly(l-glutamic acid) and

chitosan. Acta Biomater. 2013 Jul;9(7):7276-88.(IF:5.1共同通讯作者)

12.Gong L, Zhou X, Wu Y, Zhang Y, Wang C, Zhou H, Guo F, Cui L. Proteomic analysis profile of engineered articular cartilage with chondrogenic differentiated adipose tissue-derived stem cells loaded polyglycolic acid mesh for

weight-bearing area defect repair.Tissue Eng Part A. 2014 Feb;20(3-4):575-87(IF 4.5 通讯作者)

13.Wang C et al, Local injection of deferoxamine improves neovascularization in ischemic diabetic random flap by increasing HIF-1α and VEGF expression.PLoS One. 2014(IF 3.5通讯作者)

14. Zou J, et al. The graft of autologous adipose-derived stem cells in the corneal stromal after mechanic damage.PLoS One.2013 (IF 3.5通讯作者)

15. Liu G, Zhang Y, Liu B, Sun J, Li W, Cui L. Bone regeneration in a canine cranial model using allogeneic adipose derived stem cells and coral scaffold. Biomaterials. 2013 Apr;34(11):2655-64..(IF:7.8,通讯作者)

16.Wang C, Guo F, Zhou H, Zhang Y, Xiao Z, Cui L. Proteomic profiling of tissue-engineered blood vessel walls constructed by adipose-derived stem cells. Tissue Eng Part A. 2013 ;19:415-25.(IF:4.5,通讯作者)

17. Shifeng Yan,Kunxi Zhang,Zhiwen Liu, Xin Zhang,Lu Gan,Bin Cao, Xuesi Chen,Lei Cui#and Jingbo Yin. Fabrication of poly(L-glutamic acid)/chitosan polyelectrolyte complex porous scaffolds for tissue engineering. J.Mater. Chem. B, 2013, 1, 1541–1551

18.Xu J, Chen Y, Yue Y, Sun J, Cui L. Reconstruction of epidural fat with engineered adipose tissue from adipose derived stem cells and PLGA in the rabbit dorsal laminectomy model. Biomaterials. 2012 ;33(29):6965-73.(IF:7.8,通讯作者)

19. Chen F, Zhang W, Wu W, Jin Y, Cen L, Kretlow JD, Gao W, Dai Z, Wang J, Zhou G, Liu W, Cui L, Cao Y.Cryopreservation of tissue-engineered epithelial sheets in trehalose. Biomaterials. 2011 Nov;32(33):8426-35.(IF:7.8,通讯作者)

20.Gao WC, Ma SL, Cui L. Adipose-derived stem cells accelerate neovascularization in ischemic diabetic skin flap via expression of hypoxia-inducible factor-1. J Cell Mol Med. 2011;15:2575-85.(IF:4.5,通讯作者)

21.Gu H, Guo F, Zhou X, Gong L, Zhang Y, Zhai W, Chen L, Cen L, Yin S, Chang J, Cui L. The stimulation of osteogenic differentiation of human adipose-derived stem cells by ionic products from akermanite dissolution via activation of the ERK pathway. Biomaterials. 2011; 32:7023-33.(IF:7.8,通讯作者)

22. Cao B, Yan S, Zhang K, Song Z, Chen X, Cui L, Yin J. Layer-by-layer assembled multilayer films of methoxypoly (ethylene glycol)-block-poly(!,l-glutamic acid) and chitosan with reduced cell adhesion. Macromol Biosci. 2011;11:1211-7(IF:3.2,通讯作者)

23.Yan S, Yin J, Cui L, Yang Y, Chen X. Apatite-forming ability of bioactive poly(l-lactic acid)/grafted silica nanocomposites in simulated body fluid.Colloids Surf B Biointerfaces. 2011;86(1):218-24.(IF:2.5,通讯作者)

24. Cao B, Yan S, Zhang K, Song Z, Cao T, Chen X, Cui L, Yin J. A poly(acrylic acid)-block-poly(L-glutamic acid) diblock copolymer with improved cell adhesion for surface modification. Macromol Biosci. 2011;11(7):970-7.(IF:4.3,通讯作者)

25. Cao B, Yin J, Yan S, Cui L, Chen X, Xie Y. Porous scaffolds based on cross-linking of poly(L-glutamic acid).Macromol Biosci. 2011;11(3):427-34(IF:4.3,通讯作者)

26.Yin S, Cen L, Wang C, Zhao G, Sun J, Liu W, Cao Y, Cui L. Chondrogenic transdifferentiation of human dermal fibroblasts stimulated with cartilage-derived morphogenetic protein 1. Tissue Eng Part A. 2010;16: 1633-43.(IF:

4.5,通讯作者)

27.Yuan J, Zhang WJ, Liu G, Wei M, Qi ZL, Liu W, Cui L, Cao YL. Repair of canine mandibular bone defects with bone marrow stromal cells and coral. Tissue Eng Part A. 2010;16:1385-94.(IF:4.5,通讯作者)

28.Wang C, Yin S, Cen L, Liu Q, Liu W, Cao Y, Cui L.Differentiation of adipose-derived stem cells into contractile smooth muscle cells induced by transforming growth factor-beta1 and bone morphogenetic protein-4. Tissue Eng Part A. 2010;16:1201-13.(IF:4.5,通讯作者)

29. Liu G, Li Y, Sun J, Zhou H, Zhang W, Cui L, Cao Y. In vitro and in vivo evaluation of osteogenesis of human umbilical cord blood-derived mesenchymal stem cells on partially demineralized bone matrix. Tissue Eng Part A.2010;16:971-82.(IF:4.5,通讯作者)

30.Wang C, Cen L, Yin S, Liu Q, Liu W, Cao Y, Cui L. A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells. Biomaterials. 2010;31:621-30.(IF:7.8,通讯作者)

31.Wang HJ, Liu GP, Zhou GD, Cen L, Cui L, Cao Y. Comparative investigation of viability, metabolism and osteogenic capability of tissue-engineered bone preserved in sealed osteogenic media at 37 degrees C and 4 degrees

C. BIOMEDICAL MATERIALS 2010; 5: 035010(IF:1.8,通讯作者)

32. Liu Q, Cen L, Zhou H, Yin S, Liu G, Liu W, Cao Y, Cui L. The role of the extracellular signal-related kinase signaling pathway in osteogenic differentiation of human adipose-derived stem cells and in adipogenic transition

initiated by dexamethasone. Tissue Eng Part A. 2009;15:3487-97.(IF:4.5,通讯作者)

33. Cui L, Wu YH, Cen L, et al. Repair of Articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh. Biomaterials. 2009; 30:2683-2693(IF:7.8,通讯作者)

34. Zhao GQ, Yin S, Cen L, et al. In vitro engineering of fibrocartilage using CDMP1 induced dermal fibroblasts and polyglycolide. Biomaterials. 2009;30:3241-50.(IF:7.8,通讯作者)

35. Lian Cen, Koon Gee Neoh, Jian Sun, et al. Labeling of adipose derived stem cells by oleic acid modified magnetic nanoparticles. Advanced Func.Mater.2009; 19: 1158-66.(IF:9.6,通讯作者)

36. Liu Q, Cen L, Yin S,et al. A comparative study of proliferation and osteogenic differentiation of adiposederivedstem cells on akermanite and beta-TCP ceramics. Biomaterials. 2008; 29: 4792-4799.(IF:7.8,通讯作者)

37. Luo K, Yin J, Song Z, et al. Biodegradable Interpolyelectrolyte Complexes Based on Methoxy Poly(ethylene glycol)-b-poly(alpha,l-glutamic acid) and Chitosan. Biomacromolecules. 2008; 9:2653-61(IF:5.1,通讯作者)

38. Liu G, Zhou H, Li Y, et al. Evaluation of the viability and osteogenic differentiation of cryopreserved human adipose-derived stem cells. Cryobiology. 2008; 57:18-24,(IF:2.8,通讯作者)

39. Cui L,Liu B,Liu GP, et al. Repair of cranial bone defects with adipose derived stem cells and coral scaffold in a canine model. Biomaterials. 2007; 28:5477-5486(IF:7.8)

40. Jiang XG, Ye ML, Jiang XM, et al. Exploring the bone proteome: from protein identification to protein function. Method development of efficient protein extraction in bone tissue for proteome analysis, J. Proteome Res.,

2007,6:2287-2294.(IF:5.6,通讯作者)

41. Cui L,Yin S, Liu W, Li NL, Zhang WJ, Cao YL. Expanded adipose derived stem cells suppress mixed lymphocyte reaction by secretion of prostaglandin E2. Tissue Eng, 2007; 13: 1185-95(IF:4.5)

42. Jie Yuan, Cui L, Wen Jie Zhanga, Wei Liu,Yilin Cao. Repair of canine mandibular bone defects with bone marrow stromal cells and porous b-tricalcium phosphate. Biomaterials. 2007; 28: 1005-13(IF:7.8,共同第一作者)